Such people as glucosamine and chondroitin are well known to people with joint problems. And this is not by chance, since the above-listed substances are components of drugs (BOS) and dietary supplements belonging to the group of chondroprotective drugs that protect the cartilage of the joints from destruction that occurs as a result of inflammation or excessive loads.
And here, it is important to note that it is precisely the protecting, but not the reducing effect, since it is not possible to restore the destroyed cartilage by taking any substances. And, if any of the manufacturers declares the creation of a product that restores cartilage is from the evil one and should be wary of such products and their manufacturer.
After the role of chondroprotectors has become clear, it becomes clear and when they should be taken; The intake of chondroprotectors is advisable in the initial period of the disease when intra-articular cartilage is preserved, that is, a substrate is preserved that can and must be protected. However, if your knee or hip joints require surgical treatment, this does not mean that chondroprotectors should be removed, since relatively healthy joints are at risk and require attention and protection.
Now that it has become clear with the intake of chondroprotectors, it is important to understand the main active substances, namely the role of chondroitin and glucosamine in maintaining the morphological integrity and functionality of the intra-articular cartilage.
Chondroitin is a polysaccharide related to glucosamine. It is one of the most important components of hyaline cartilage and is part of the synovial fluid. Chondroitin provides the strength of the tendons and provides the necessary density of cartilage tissue. No less important property of chondroitin is its ability to suppress enzymes involved in the destruction of cartilage tissue. The role of chondroitin is important in ensuring the production of synovial fluid-substrate, performing a function similar to oils in moving mechanisms, that is, optimal joint mobility.
However, the beneficial effect of chondroitin is not limited to this. The positive effect of chondroitin on the cardiovascular, endocrine, musculoskeletal, reproductive and other body systems has been established.
On average, an adult needs 800-1200 mg of chondroitin per day. A certain amount is produced by the body. The rest we get with food.
An equally important component is glucosamine. Glucosamine is a molecule that contains amine and glucose. As well as chondroitin, it is present in food products, but in smaller quantities. The ability of cartilage cells to produce glucosamine by itself is noted. But, to ensure its optimal production, only healthy cartilage tissue is capable.
Being essentially a precursor of chondroitin, glucosamine has a similar effect. Thanks to it, the synthesis of proteoglycans and hyaluronic acid of the synovial fluid is ensured; increases the permeability of the articular capsule, restores enzymatic processes in the cells of the synovial membrane and articular cartilage. Glucosamine contributes to sulfur fixation during the synthesis of chondroitin-sulfuric acid, facilitates normal calcium deposition in bone tissue, inhibits the development of degenerative processes in the joints, restores their function and helps reduce pain in damaged joints. The daily intake of glucosamine is 1500 mg.
As mentioned earlier, chondroitin and glucosamine can be synthesized in the body, but to a greater extent their need is closed by food. The most useful and rich in these substances are fish and other seafood. In addition, seafood is well digested, does not contain, unlike meat, cholesterol and can be considered as elements of a diet.
Other sources of glucosamine and chondroitin are: meat, vegetables, dairy products. But to close the needs of the body due to the intake of chondroitin and glucosamine with food and develop your own, it is possible only if the body functions normally, there are no pathological processes in the gastrointestinal tract and no inflammatory diseases of the musculoskeletal system.
The presence of inflammatory diseases of the joints, osteoarthritis, dramatically increases the body’s need for these substances. Also, the need for glucosamine and chondroitin increases sharply in individuals performing heavy physical exertion, in which all large joints are involved.
In such cases, it is possible to compensate for the needs of glucosamine and chondroitin by taking chondroprotectors. As mentioned at the beginning of the article, chondroprotectors can be represented as drugs and dietary supplements, while the division between them is rather arbitrary. At the same time, it is important that chondroprotector contains both glucosamine and chondroitin, as this complex is recognized as the most effective. All chondroprotectors of the latest generation incorporate both molecules.
By their origin, chondroprotectors can be of plant, animal, or synthetic origin. Herbal preparations are extremely rare and have a high cost, which significantly limits their use.
As for synthetic drugs, their main disadvantages are the relatively low digestibility and the presence of side effects, especially on the side of the gastrointestinal tract.
Chondroprotectors of animal origin can be considered optimal. The raw material for their preparation can be cattle cartilage tissue (CS) or cartilage tissue of fish and other sea creatures (squids). In this case, drugs of marine origin can be considered as the most optimal, both in terms of bioavailability and due to the highest degree of anti-inflammatory activity. It is anti-inflammatory activity that provides rapid elimination of pain, and high bioavailability allows for a therapeutic effect with a low content of chondroitin and glucosamine, with a minimal risk of adverse events.
In the Russian Federation, the manufacturer of the protector based on the inhabitants of the depths of the sea, is the company FarmOns Lab., Which produces the drug ARTROFISH, created on the basis of the cartilage of shark, squid, salmon and stingray. This product has proven itself as in individuals with the initial stages of osteoarthritis, and in healthy individuals experiencing a high load on the musculoskeletal system.