Far Eastern fishes of the salmon family are a magnificent seven: pink salmon, chum salmon, silver salmon, sockeye salmon, chinook salmon, kunja and char. Salmon are one of the main industrial fishing facilities in the Pacific region, and everything goes from head to tail. Scientists have found that cartilage tissue and milt salmon, which usually go to waste, have a lot of healthy properties.
Salmon cartilage tissues are the basis of drugs and dietary supplements, in particular, helping with diseases of the joints – they contain biologically active substances (BAS) that nourish and restore human cartilage tissue, which suffers from arthritis, arthritis, osteochondrosis.
Osteoarthritis is a disease of the joints caused by a lesion of cartilage tissue, which affects at least 20% of the world’s population. The number of patients with osteoarthritis (OA) will grow in the future due to the increase in life expectancy of people, in the past many people simply did not live to see manifestations of OA. OA is currently considered one of the five main causes of temporary disability, and arthrosis of the hip joints (coxarthrosis) and knee joints (gonarthrosis) often lead to disability.
Cartilage connective tissue cells – chondrocytes – produce carbohydrate-protein complexes (proteoglycans, glycosaminoglycans – GAG), are involved in the formation of fibrous structures (elastin, collagen). GAGs provide the ability of cartilage to function normally, to withstand considerable pressure, to recover from the load. With the destruction of cartilage, the concentration of GAG decreases, the resistance of the intercellular substance to physical impact decreases and the surface of the cartilage becomes sensitive to damage.
With the progression of diseases of the joints, the GAG content is not fully normalized, the cartilage becomes turbid, dry, loosened, loses its basic properties.
To preserve the integrity of the cartilage and its functions, constant synthesis of GAG, proteoglycans and collagen is necessary in a volume equal to the amount lost. However, with OA, the synthesis process is disrupted.
The main tasks in the treatment of OA are to stop the destruction of cartilage, reduce inflammation, normalize metabolic processes in cartilage, reduce pain and improve joint function. Currently, there are two directions in the treatment of OA: a rapid decrease in pain and inflammatory changes in the joints, as well as a slowdown in the degradation of cartilage components and disease progression.
The first direction – the use of nonsteroidal anti-inflammatory drugs (NSAIDs) has many side effects and does not help the restoration of cartilage tissue, the second direction – the use of delayed-effect biologics, chondroprotectors, restoring cartilage. Such slow-acting drugs include glucosamine and chondroitin sulfates, which are structural analogues of cartilage glucosaminoglycans. Chondroprotectors are a mandatory component of the complex therapy of osteoarthritis.
The advantages of their use in clinical practice: pain relief, improvement of joint function, maintaining the effect after the end of treatment, the absence of serious side effects, slowing the progression of the disease.
In recent decades, a great interest is caused by the work on obtaining chondroprotectors from the cartilage tissue of marine hydrobionts. The argument for the use of waste fish and other hydrobionts is their considerable volume and high content of biologically active substances, especially chondroitin sulfate, in the waste of cartilage fish.
Natural chondroitin sulfate, hexosamine, soluble collagen and other substances that are well absorbed, safe and have a wide range of applications, are isolated from salmon cartilage tissues using the enzymatic hydrolysis method.
Milk salmon, since the 70s of the last century, serve as a source for the selection of deoxyribonucleic acid (DNA).
Limiting the use of DNA in the composition of various dietary supplements, food and cosmetic products, its poor solubility, to eliminate this disadvantage, a method of enzymatic hydrolysis was created for processing milk to obtain soluble components.
From DNA, nucleoproteins are obtained that effectively increase immunity, normalize serum cholesterol levels, improve the functioning of the reproductive system , help fight pathogenic microorganisms, and promote the elimination of free radicals from the body. The uniqueness of nucleoproteins and their effectiveness is due to the high biological activity of the specific proteins contained in them: protamines (salmins).
Studies by Far Eastern scientists have proved the clinical efficacy of low molecular weight DNA (nDNA) as a means of supplementing basic therapy for various diseases.
Effect of nDNA on the central nervous system.
Hydrolyzed molok salmon has a stimulating and tonic effects , increasing physical performance. Also optimized processes of bioelectric activity of the brain. NDNA increases the efficiency of higher nervous activity, improves the functioning of the vascular system.
Effect of nDNA on the state of the immune and antioxidant systems in the elderly.
For the elderly is characterized by a decrease in antimicrobial immunity, antiviral and antitumor protection. The accumulation of damage in cells and the rate of aging also depend on the ratio of the processes of formation of free radicals (reactive oxygen species) and their neutralization by the antioxidant defense system of the body. Free radicals cause mutations and the development of a number of age-related pathologies, in particular, cancer and cardiovascular diseases, deterioration of the brain, cataracts.
The use of biopreparations based on substances such as salmon milt will help break the “aging-disease” pathological link and reduce the risks of developing age-related pathology .
It should be taken into account that many diseases have become “much younger” in recent decades, therefore, preparations based on salmon milt can be of great benefit to people of working age.
The use of nDNA preparations in oncology
DNA preparations are recommended for almost all patients receiving chemotherapy or radiation therapy to stimulate blood formation, reduce various adverse side effects associated with the cardiovascular system during drug therapy (cardiotoxicity) and reduce the damaging effect of chemotherapy drugs on the hematopoietic tissue of the bone marrow (myelotoxicity ).
Success in the treatment of cancer is also explained by the ability of DNA to accumulate in critical tissues and serve as a conductor for an antitumor drug (cytostatic).
Another important component of salmon milt is phospholipids. They contain polyunsaturated acids (lysine, arginine, taurine), which inhibit cell aging, improve memory, help the liver.